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Nicholas Alonzo Frost
( out of 166 reviews )

Nicholas Alonzo Frost, MD, PhD

Languages spoken: English

  • Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

    Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

    Specialties

    Board Certification

    American Board of Psychiatry & Neurology (Neurology)

    Patient Rating

    4.9 /5
    ( out of 166 reviews )

    The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers.

    The scale on which responses are measured is 1 to 5 with 5 being the best score.

    Patient Comments

    Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

    July 18, 2025
    CLINICAL NEUROSCIENCES CENTER

    Very professional

    June 16, 2025
    CLINICAL NEUROSCIENCES CENTER

    I'm very thankful for his help & devotion to my issue.

    May 29, 2025
    CLINICAL NEUROSCIENCES CENTER

    Dr. Frost is very knowledgeable. He listens and gives honest feedback. He shares information so you can make our own decision for what is best for you. His staff is very helpful and professional-also they really care.

    May 25, 2025
    CLINICAL NEUROSCIENCES CENTER

    Dr. Frost has a great way of while being professional he explains thing well so less educated in his area of specialty can understand. He's empathetic and wants to make sure my husband is getting all care available to him.

    May 18, 2025
    CLINICAL NEUROSCIENCES CENTER

    He is very good but hard to see, booking apps 6 months out

    May 04, 2025
    CLINICAL NEUROSCIENCES CENTER

    Great doctor

    April 24, 2025
    CLINICAL NEUROSCIENCES CENTER

    I'm very happy with Dr Frost. He and his staff are very good.

    April 11, 2025
    CLINICAL NEUROSCIENCES CENTER

    I totally respect Dr. Frost and his team. He explains things so that I understand what he is going to do and what is going to happen next in my treatment plan. I am so happy that I chose to go with the U of U for my treatment plan.

    March 23, 2025
    CLINICAL NEUROSCIENCES CENTER

    Great doctor! I would recommend him to anyone that needs to see a Neurologist. He explains everything he is going to do.

    See More Patient Comments

  • Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

    Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

    Board Certification and Academic Information

    Academic Departments Neurology -Assistant Professor
    Neurobiology -Adjunct Assistant Professor
    Board Certification
    American Board of Psychiatry & Neurology (Neurology)

    Education history

    Research Fellow R25 Research Fellowship in circuit disorders underlying abnormal behavior - University of California, San Francisco Postdoctoral Fellow
    Residency Neurology - University of California, San Francisco Resident
    Internship Internal Medicine - University of California, San Francisco Intern
    Professional Medical Neuroscience - University of Maryland School of Medicine M.D., Ph.D.
    Undergraduate Biochemistry, Spanish - Florida State University B.S., B.A.

    Selected Publications

    Journal Article

    1. Walker H, Frost NA (2024). Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction. STAR Protoc, 5(4), 103395. ()
    2. Walker H, Frost NA (2023). Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction. iScience. ()
    3. Walker H, Frost NA (2024). Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction. iScience, 27(7), 110355. ()
    4. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ (2024). Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Cell Stem Cell, 31(3), 421-432.e8. ()
    5. Frost NA, Donohue KC, Sohal V (2023). Context-invariant socioemotional encoding by prefrontal ensembles. bioRxiv. ()
    6. Frost NA, Haggart A, Sohal VS (2021). Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biol, May 3;19(5), e3001235.
    7. MacGillavry HD, Kerr JM, Kassner J, Frost NA, Blanpied TA (2015). Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses. Eur J Neurosci, 43(2), 179-93. ()
    8. Lu HE, MacGillavry HD, Frost NA, Blanpied TA (2014). Multiple spatial and kinetic subpopulations of CaMKII in spines and dendrites as resolved by single-molecule tracking PALM. J Neurosci, 34(22), 7600-10. ()
    9. Jensen CS, Watanabe S, Rasmussen HB, Schmitt N, Olesen SP, Frost NA, Blanpied TA, Misonou H (2014). Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons. J Biol Chem, 289(15), 10566-81. ()
    10. Parikh RV, Frost NA, Green A, Dandu M (2014). A Leathery Lining. J Gen Intern Med, 29(1), 243.
    11. Lieberman JA, Frost NA, Hoppert M, Fernandes PJ, Vogt SL, Raivio TL, Blanpied TA, Donnenberg MS (2012). Outer membrane targeting, ultrastructure, and single molecule localization of the enteropathogenic Escherichia coli type IV pilus secretin BfpB. J Bacteriol, 194(7), 1646-58. ()
    12. Frost NA, Lu HE, Blanpied TA (2012). Optimization of cell morphology measurement via single-molecule tracking PALM. PLoS One, 7(5), e36751. ()
    13. Frost NA, Kerr JM, Lu HE, Blanpied TA (2010). A network of networks: cytoskeletal control of compartmentalized function within dendritic spines. Curr Opin Neurobiol, 20(5), 578-87. ()
    14. Frost NA, Shroff H, Kong H, Betzig E, Blanpied TA (2010). Single-molecule discrimination of discrete perisynaptic and distributed sites of actin filament assembly within dendritic spines. Neuron, 67(1), 86-99. ()
    15. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M (2009). PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol, 297(6), F1560-5. ()
    16. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C (2006). Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res, 66(15), 7578-88. ()

    Book Chapter

    1. Frost NA, MacGillavry HD, Lu HE, Blanpied TA (2014). Live-cell PALM of intracellular proteins in neurons. In Nägerl U, Triller A (Eds.), Nanoscale Imaging of Synapses. Neuromethods (84, pp. 93-123). New York, NY: Humana Press.